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Speckle Tracking Stress Echocardiography Uncovers Early Subclinical Cardiac Involvement in Pediatric Patients with Inflammatory Bowel Diseases.


ABSTRACT: Inflammatory bowel disease (IBD) is an established risk factor for cardiovascular disease (CVD). However, whether cardiac consequences present early in IBD is unknown. This is the first study in children aiming to unmask altered myocardial mechanics in IBD. We enrolled 50 consecutive normotensive children with Crohn's disease (CD) (n?=?28) or ulcerative colitis (UC) (n?=?22). The study groups consisted of 18 patients with active inflammatory disease (mean age 14.6?±?2.5 years) and 32 children with IBD in remission (14.3?±?2.3 years). 60 age- and gender-matched children served as healthy controls. Speckle tracking stress echocardiography (STE) was used to assess left ventricular (LV) myocardial strain and strain rate. Circumferential strain rate was significantly decreased in children with active IBD (-1.55?±?0.26?s-1) and IBD in remission (-1.49?±?0.26?s-1) versus healthy controls (1.8?±?0.4?s-1) both at rest (p?

SUBMITTER: Hensel KO 

PROVIDER: S-EPMC5462781 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Speckle Tracking Stress Echocardiography Uncovers Early Subclinical Cardiac Involvement in Pediatric Patients with Inflammatory Bowel Diseases.

Hensel Kai O KO   Abellan Schneyder Francisca E FE   Wilke Lucia L   Heusch Andreas A   Wirth Stefan S   Jenke Andreas C AC  

Scientific reports 20170607 1


Inflammatory bowel disease (IBD) is an established risk factor for cardiovascular disease (CVD). However, whether cardiac consequences present early in IBD is unknown. This is the first study in children aiming to unmask altered myocardial mechanics in IBD. We enrolled 50 consecutive normotensive children with Crohn's disease (CD) (n = 28) or ulcerative colitis (UC) (n = 22). The study groups consisted of 18 patients with active inflammatory disease (mean age 14.6 ± 2.5 years) and 32 children wi  ...[more]

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