Genetic and epigenetic control of gene expression by CRISPR-Cas systems.
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ABSTRACT:
SUBMITTER: Lo A
PROVIDER: S-EPMC5464239 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
<b>Genetic and epigenetic control of gene expression by CRISPR-Cas systems</b>.
F1000Research 20170525
The discovery and adaption of bacterial clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) systems has revolutionized the way researchers edit genomes. Engineering of catalytically inactivated Cas variants (nuclease-deficient or nuclease-deactivated [dCas]) combined with transcriptional repressors, activators, or epigenetic modifiers enable sequence-specific regulation of gene expression and chromatin state. These CRISPR-Cas-based technologies have contrib ...[more]
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