Dataset Information

Multigene signature for predicting prognosis of patients with 1p19q co-deletion diffuse glioma.

ABSTRACT:

Background

Co-deletion of 1p and 19q marks a diffuse glioma subtype associated with relatively favorable overall survival; however, heterogeneous clinical outcomes are observed within this category.

Methods

We assembled gene expression profiles and sample annotation of 374 glioma patients carrying the 1p/19q co-deletion. We predicted 1p/19q status using gene expression when annotation was missing. A first cohort was randomly split into training (n = 170) and a validation dataset (n = 163). A second validation set consisted of 41 expression profiles. An elastic-net penalized Cox proportional hazards model was applied to build a classifier model through cross-validation within the training dataset.

Results

The selected 35-gene signature was used to identify high-risk and low-risk groups in the validation set, which showed significantly different overall survival (P = .00058, log-rank test). For time-to-death events, the high-risk group predicted by the gene signature yielded a hazard ratio of 1.78 (95% confidence interval, 1.02-3.11). The signature was also significantly associated with clinical outcome in the The Cancer Genome Atlas (CGA) IDH-mutant 1p/19q wild-type and IDH-wild-type glioma cohorts. Pathway analysis suggested that high risk was associated with increased acetylation activity and inflammatory response. Tumor purity was found to be significantly decreased in high-risk IDH-mutant with 1p/19q co-deletion gliomas and IDH-wild-type glioblastomas but not in IDH-wild-type lower grade or IDH-mutant, non-co-deleted gliomas.

Conclusion

We identified a 35-gene signature that identifies high-risk and low-risk categories of 1p/19q positive glioma patients. We have demonstrated heterogeneity amongst a relatively new glioma subtype and provided a stepping stone towards risk stratification.

SUBMITTER: Hu X

PROVIDER: S-EPMC5464432 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Publications

Multigene signature for predicting prognosis of patients with 1p19q co-deletion diffuse glioma.

Hu Xin X Martinez-Ledesma Emmanuel E Zheng Siyuan S Kim Hoon H Barthel Floris F Jiang Tao T Hess Kenneth R KR Verhaak Roel G W RGW

Neuro-oncology 20170601 6

<h4>Background</h4>Co-deletion of 1p and 19q marks a diffuse glioma subtype associated with relatively favorable overall survival; however, heterogeneous clinical outcomes are observed within this category.<h4>Methods</h4>We assembled gene expression profiles and sample annotation of 374 glioma patients carrying the 1p/19q co-deletion. We predicted 1p/19q status using gene expression when annotation was missing. A first cohort was randomly split into training (n = 170) and a validation dataset ( ...[more]

PMID: 28340142

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Dataset Information

Multigene signature for predicting prognosis of patients with 1p19q co-deletion diffuse glioma.

Background

Methods

Results

Conclusion

Publications

Multigene signature for predicting prognosis of patients with 1p19q co-deletion diffuse glioma.

Similar Datasets

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