Dataset Information

Kidney volume to GFR ratio predicts functional improvement after revascularization in atheromatous renal artery stenosis.

ABSTRACT:

Background

Randomized controlled trials (RCT) have shown no overall benefit of renal revascularization in atherosclerotic renovascular disease (ARVD). However, 25% of patients demonstrate improvement in renal function. We used the ratio of magnetic resonance parenchymal volume (PV) to isotopic single kidney glomerular filtration rate (isoSKGFR) ratio as our method to prospectively identify "improvers" before revascularization.

Methods

Patients with renal artery stenosis who were due revascularization were recruited alongside non-ARVD hypertensive CKD controls. Using the controls, 95% CI were calculated for expected PV:isoSK-GFR at given renal volumes. For ARVD patients, "improvers" were defined as having both >15% and >1ml/min increase in isoSK-GFR at 4 months after revascularization. Sensitivity and specificity of PV:isoSK-GFR for predicting improvers was calculated.

Results

30 patients (mean age 68 ±8 years), underwent revascularization, of whom 10 patients had intervention for bilateral RAS. Stented kidneys which manifested >15% improvement in function had larger PV:isoSK-GFR compared to controls (19±16 vs. 6±4ml/ml/min, p = 0.002). The sensitivity and specificity of this equation in predicting a positive renal functional outcome were 64% and 88% respectively. Use of PV:isoSK-GFR increased prediction of functional improvement (area under curve 0.93). Of note, non-RAS contralateral kidneys which improved (n = 5) also demonstrated larger PV:isoSK-GFR (15.2±16.2 ml/ml/min, p = 0.006).

Conclusion

This study offers early indicators that the ratio of PV:isoSK-GFR may help identify patients with kidneys suitable for renal revascularization which could improve patient selection for a procedure associated with risks. Calculation of the PV:isoSK-GFR ratio is easy, does not require MRI contrast agent.

SUBMITTER: Chrysochou C

PROVIDER: S-EPMC5464522 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Kidney volume to GFR ratio predicts functional improvement after revascularization in atheromatous renal artery stenosis.

Chrysochou Constantina C Green Darren D Ritchie James J Buckley David L DL Kalra Philip A PA

PloS one 20170608 6

<h4>Background</h4>Randomized controlled trials (RCT) have shown no overall benefit of renal revascularization in atherosclerotic renovascular disease (ARVD). However, 25% of patients demonstrate improvement in renal function. We used the ratio of magnetic resonance parenchymal volume (PV) to isotopic single kidney glomerular filtration rate (isoSKGFR) ratio as our method to prospectively identify "improvers" before revascularization.<h4>Methods</h4>Patients with renal artery stenosis who were d ...[more]

PMID: 28594847

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Dataset Information

Kidney volume to GFR ratio predicts functional improvement after revascularization in atheromatous renal artery stenosis.

Background

Methods

Results

Conclusion

Publications

Kidney volume to GFR ratio predicts functional improvement after revascularization in atheromatous renal artery stenosis.

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