MiR-29a regulated ER-positive breast cancer cell growth and invasion and is involved in the insulin signaling pathway.

ABSTRACT: Increasing amounts of evidence show that insulin can activate different insulin signaling pathways to promote breast cancer growth and invasion. miR-29a plays crucial roles in decreasing glucose-stimulated insulin secretion, as well as in regulating breast cancer cell proliferation and EMT. However, the mechanism responsible for the regulatory effects of miR-29a on breast cancer growth and invasion and the relationship between these effects and insulin signaling remains unclear. Herein, we showed that human insulin increased miR-29a expression in ER-positive breast cancer cells and that miR-29a facilitated the ability of insulin to promote breast cancer cell proliferation and migration. We found that miR-29a-induced cell proliferation and metastasis acceleration occurred primarily through

SUBMITTER: Li ZH 

PROVIDER: S-EPMC5464809 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature