NID1, a new regulator of EMT required for metastasis and chemoresistance of ovarian cancer cells.
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ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC5464854 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
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NID1, a new regulator of EMT required for metastasis and chemoresistance of ovarian cancer cells.
Zhou Ya Y Zhu Yuanyuan Y Fan Xiaoyan X Zhang Chundong C Wang Yitao Y Zhang Lian L Zhang Huan H Wen Tao T Zhang Kaina K Huo Xiao X Jiang Xue X Bu Youquan Y Zhang Ying Y
Oncotarget 20170501 20
Nidogen-1 (NID1) has been identified as a novel candidate diagnostic biomarker of ovarian cancer in our previous study. Nevertheless, the role of NID1 in the pathogenesis of ovarian cancer is unclear. In the present study, we demonstrated that NID1 was a mesenchymal associated gene and its high expression was significantly correlated with shorter overall survival of ovarian cancer patients. The ectopic expression of NID1 in OVCAR-3 cells revealed a epithelial-mesenchymal transition (EMT) phenoty ...[more]
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