Ontology highlight
ABSTRACT:
SUBMITTER: Bell EH
PROVIDER: S-EPMC5464982 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Bell Erica Hlavin EH Pugh Stephanie L SL McElroy Joseph P JP Gilbert Mark R MR Mehta Minesh M Klimowicz Alexander C AC Magliocco Anthony A Bredel Markus M Robe Pierre P Grosu Anca-L AL Stupp Roger R Curran Walter W Becker Aline P AP Salavaggione Andrea L AL Barnholtz-Sloan Jill S JS Aldape Kenneth K Blumenthal Deborah T DT Brown Paul D PD Glass Jon J Souhami Luis L Lee R Jeffrey RJ Brachman David D Flickinger John J Won Minhee M Chakravarti Arnab A
JAMA oncology 20170601 6
<h4>Importance</h4>There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in the temozolomide era.<h4>Objective</h4>To refine the existing clinically based recursive partitioning analysis (RPA) model by incorporating molecular variables.<h4>Design, setting, and participants</h4>NRG Oncology RTOG 0525 specimens (n = 452) were analyzed for protein biomarkers representing key pathways in GBM by a quantitative molecular microscopy-based approach with semiqu ...[more]