Ontology highlight
ABSTRACT:
SUBMITTER: Male AL
PROVIDER: S-EPMC5465072 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Male Abigail L AL Forafonov Fedor F Cuda Francesco F Zhang Gong G Zheng Siqi S Oyston Petra C F PCF Chen Peng R PR Williamson E Diane ED Tavassoli Ali A
Scientific reports 20170608 1
The protein-protein interaction between the human CMG2 receptor and the Bacillus anthracis protective antigen (PA) is essential for the transport of anthrax lethal and edema toxins into human cells. We used a genetically encoded high throughput screening platform to screen a SICLOPPS library of 3.2 million cyclic hexapeptides for inhibitors of this protein-protein interaction. Unusually, the top 3 hits all contained stop codons in the randomized region of the library, resulting in linear rather ...[more]