Ontology highlight
ABSTRACT:
SUBMITTER: Noguchi H
PROVIDER: S-EPMC5465209 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Noguchi Hirofumi H Sugimoto Koji K Miyagi-Shiohira Chika C Nakashima Yoshiki Y Kobayashi Naoya N Saitoh Issei I Watanabe Masami M Noguchi Yasufumi Y
Scientific reports 20170608 1
Calcineurin inhibitors have been used for transplant therapy. However, the inhibition of calcineurin outside the immune system has a number of side effects. We previously developed a cell-permeable inhibitor of NFAT (nuclear factor of activated T cells) using the polyarginine peptide delivery system. This peptide (11R-VIVIT) selectively interferes with calcineurin-NFAT interaction without affecting the activity of calcineurin phosphatase and provides immunosuppression for fully mismatched islet ...[more]