Cognitive Variability during Middle-Age: Possible Association with Neurodegeneration and Cognitive Reserve.

ABSTRACT: Objective: Increased variability in cognition with age has been argued as an indication of pathological processes. Focusing on early detection of neurodegenerative disorders, we investigated variability in cognition in healthy middle-aged adults. In order to understand possible determinants of this variability, we also investigated associations with cognitive reserve, neuroimaging markers, subjective memory complaints, depressive symptomatology, and gender. Method: Thirty-one 50 ± 2 years old individuals were investigated as target group and deviation was studied in comparison to a reference younger group of 30 individuals 40 ± 2 years old. Comprehensive neuropsychological and structural imaging protocols were collected. Brain regional volumes and cortical thickness were calc

SUBMITTER: Ferreira D 

PROVIDER: S-EPMC5465264 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature