Ontology highlight
ABSTRACT:
SUBMITTER: Ratsimandresy RA
PROVIDER: S-EPMC5465353 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Ratsimandresy Rojo A RA Chu Lan H LH Khare Sonal S de Almeida Lucia L Gangopadhyay Anu A Indramohan Mohanalaxmi M Misharin Alexander V AV Greaves David R DR Perlman Harris H Dorfleutner Andrea A Stehlik Christian C
Nature communications 20170605
Inflammasomes are protein platforms linking recognition of microbe, pathogen-associated and damage-associated molecular patterns by cytosolic sensory proteins to caspase-1 activation. Caspase-1 promotes pyroptotic cell death and the maturation and secretion of interleukin (IL)-1β and IL-18, which trigger inflammatory responses to clear infections and initiate wound-healing; however, excessive responses cause inflammatory disease. Inflammasome assembly requires the PYRIN domain (PYD)-containing a ...[more]