Ontology highlight
ABSTRACT:
SUBMITTER: Guidoboni M
PROVIDER: S-EPMC546537 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Guidoboni Massimo M Ponzoni Maurilio M Caggiari Laura L Lettini Antonia A AA Vago Luca L De Re Valli V Gloghini Annunziata A Zancai Paola P Carbone Antonino A Boiocchi Mauro M Dolcetti Riccardo R
Journal of virology 20050201 4
The origin and biological significance of deletions at the 3' end of the Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP-1) gene are still controversial. We herein demonstrate that LMP-1 deletion mutants are highly associated with human immunodeficiency virus-related Hodgkin's lymphoma (HIV-HL) of Italian patients (29 of 31 cases; 93.5%), a phenomenon that is not due to a peculiar distribution of EBV strains in this area. In fact, although HIV-HL patients are infected by multiple ...[more]