Ontology highlight
ABSTRACT:
SUBMITTER: Wan J
PROVIDER: S-EPMC5466421 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Wan Jun J Su Yijing Y Song Qifeng Q Tung Brian B Oyinlade Olutobi O Liu Sheng S Ying Mingyao M Ming Guo-Li GL Song Hongjun H Qian Jiang J Zhu Heng H Xia Shuli S
eLife 20170529
Altered DNA methylation status is associated with human diseases and cancer; however, the underlying molecular mechanisms remain elusive. We previously identified many human transcription factors, including Krüppel-like factor 4 (KLF4), as sequence-specific DNA methylation readers that preferentially recognize methylated CpG (mCpG), here we report the biological function of mCpG-dependent gene regulation by KLF4 in glioblastoma cells. We show that KLF4 promotes cell adhesion, migration, and morp ...[more]