Ontology highlight
ABSTRACT:
SUBMITTER: Narayanan C
PROVIDER: S-EPMC5466627 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Narayanan Chitra C Gagné Donald D Reynolds Kimberly A KA Doucet Nicolas N
Scientific reports 20170609 1
In this work, we applied the sequence-based statistical coupling analysis approach to characterize conserved amino acid networks important for biochemical function in the pancreatic-type ribonuclease (ptRNase) superfamily. This superfamily-wide analysis indicates a decomposition of the RNase tertiary structure into spatially distributed yet physically connected networks of co-evolving amino acids, termed sectors. Comparison of this statistics-based description with new NMR experiments data shows ...[more]