Ontology highlight
ABSTRACT:
SUBMITTER: Zhang XY
PROVIDER: S-EPMC5466671 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Zhang Xiao-Yu XY Ng Tsz Kin TK Brelén Mårten Erik ME Chan Kwok Ping KP Wu Di D Yung Jasmine Sum Yee JSY Cao Di D Wang Yumeng Y Zhang Shaodan S Chan Sun On SO Pang Chi Pui CP
Scientific reports 20170609 1
Cigarette smoking is a major risk factor for age-related macular degeneration (AMD), in which progressive retinal pigment epithelial (RPE) cell degeneration is a major pathological change. Nicotine is a major biologically active component in cigarette smoke. It is continuously catabolized into cotinine, which has longer half-life and higher concentration in tissue cells and fluids. Here we hypothesized that continuous exposure of cotinine has more potent effects on human RPE cell properties than ...[more]