Synaptic mechanisms underlying persistent cocaine craving.
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ABSTRACT:
SUBMITTER: Wolf ME
PROVIDER: S-EPMC5466704 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Synaptic mechanisms underlying persistent cocaine craving.
Nature reviews. Neuroscience 20160506 6
Although it is challenging for individuals with cocaine addiction to achieve abstinence, the greatest difficulty is avoiding relapse to drug taking, which is often triggered by cues associated with prior cocaine use. This vulnerability to relapse persists for long periods (months to years) after abstinence is achieved. Here, I discuss rodent studies of cue-induced cocaine craving during abstinence, with a focus on neuronal plasticity in the reward circuitry that maintains high levels of craving. ...[more]
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