Dataset Information

Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database.

ABSTRACT: OBJECTIVE:Using a large U.S. claims database (MarketScan), we investigated the controversy surrounding the role of statins in Parkinson's disease (PD). METHODS:We performed a retrospective case-control analysis. First, we identified 2322 incident PD cases having a minimum of 2.5 years of continuous enrollment prior to earliest diagnosis code or prescription of antiparkinson medication. A total of 2322 controls were then matched individually by age, gender, and a follow-up window to explore the relationship of statin use with incident PD. RESULTS:Statin usage was significantly associated with PD risk, with the strongest associations being for lipophilic (odds ratio = 1.58, P < .0001) versus hydrophilic (odds ratio = 1.19, P = .25) statins, statins plus nonstatins (odds ratio = 1.95, P < .0001), and for the initial period after starting statins (<1 year odds ratio = 1.82, 1-2.5 years odds ratio = 1.75, and ?2.5 years odds ratio = 1.37; Ptrend < .0001). CONCLUSION:The use of statin (especially lipophilics) was associated with higher risk of PD, and the stronger association in initial use suggests a facilitating effect. © 2017 International Parkinson and Movement Disorder Society.

SUBMITTER: Liu G

PROVIDER: S-EPMC5466869 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database.

Liu Guodong G Sterling Nicholas W NW Kong Lan L Lewis Mechelle M MM Mailman Richard B RB Chen Honglei H Leslie Douglas D Huang Xuemei X

Movement disorders : official journal of the Movement Disorder Society 20170403 6

<h4>Objective</h4>Using a large U.S. claims database (MarketScan), we investigated the controversy surrounding the role of statins in Parkinson's disease (PD).<h4>Methods</h4>We performed a retrospective case-control analysis. First, we identified 2322 incident PD cases having a minimum of 2.5 years of continuous enrollment prior to earliest diagnosis code or prescription of antiparkinson medication. A total of 2322 controls were then matched individually by age, gender, and a follow-up window t ...[more]

PMID: 28370314

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Dataset Information

Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database.

Publications

Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database.

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