Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5467209 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Wang Yuxi Y Yu Yamei Y Li Guo-Bo GB Li Shu-Ang SA Wu Chengyong C Gigant Benoît B Qin Wenming W Chen Hao H Wu Yangping Y Chen Qiang Q Yang Jinliang J
Nature communications 20170606
As a major component of the cytoskeleton, microtubules consist of αβ-tubulin heterodimers and have been recognized as attractive targets for cancer chemotherapy. Microtubule-stabilizing agents (MSAs) promote polymerization of tubulin and stabilize the polymer, preventing depolymerization. The molecular mechanisms by which MSAs stabilize microtubules remain elusive. Here we report a 2.05 Å crystal structure of tubulin complexed with taccalonolide AJ, a newly identified taxane-site MSA. Taccalonol ...[more]