Ontology highlight
ABSTRACT:
SUBMITTER: Xu M
PROVIDER: S-EPMC5467248 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Nature communications 20170607
Human WNT10A mutations are associated with developmental tooth abnormalities and adolescent onset of a broad range of ectodermal defects. Here we show that β-catenin pathway activity and adult epithelial progenitor proliferation are reduced in the absence of WNT10A, and identify Wnt-active self-renewing stem cells in affected tissues including hair follicles, sebaceous glands, taste buds, nails and sweat ducts. Human and mouse WNT10A mutant palmoplantar and tongue epithelia also display specific ...[more]