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Centromeres Drive a Hard Bargain.

ABSTRACT: Centromeres are essential chromosomal structures that mediate the accurate distribution of genetic material during meiotic and mitotic cell divisions. In most organisms, centromeres are epigenetically specified and propagated by nucleosomes containing the centromere-specific H3 variant, centromere protein A (CENP-A). Although centromeres perform a critical and conserved function, CENP-A and the underlying centromeric DNA are rapidly evolving. This paradox has been explained by the centromere drive hypothesis, which proposes that CENP-A is undergoing an evolutionary tug-of-war with selfish centromeric DNA. Here, we review our current understanding of CENP-A evolution in relation to centromere drive and discuss classical and recent advances, including new evidence implicating CENP-A chaperones in this conflict.

SUBMITTER: Rosin LF

PROVIDER: S-EPMC5467322 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Centromeres Drive a Hard Bargain.

Rosin Leah F LF Mellone Barbara G BG

Trends in genetics : TIG 20170107 2

Centromeres are essential chromosomal structures that mediate the accurate distribution of genetic material during meiotic and mitotic cell divisions. In most organisms, centromeres are epigenetically specified and propagated by nucleosomes containing the centromere-specific H3 variant, centromere protein A (CENP-A). Although centromeres perform a critical and conserved function, CENP-A and the underlying centromeric DNA are rapidly evolving. This paradox has been explained by the centromere dri ...[more]

PMID: 28069312

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Dataset Information

Centromeres Drive a Hard Bargain.

Publications

Centromeres Drive a Hard Bargain.

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