Ontology highlight
ABSTRACT:
SUBMITTER: Bahari-Javan S
PROVIDER: S-EPMC5468618 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20170522 23
Schizophrenia is a devastating disease that arises on the background of genetic predisposition and environmental risk factors, such as early life stress (ELS). In this study, we show that ELS-induced schizophrenia-like phenotypes in mice correlate with a widespread increase of histone-deacetylase 1 (<i>Hdac1</i>) expression that is linked to altered DNA methylation. <i>Hdac1</i> overexpression in neurons of the medial prefrontal cortex, but not in the dorsal or ventral hippocampus, mimics schizo ...[more]