Ontology highlight
ABSTRACT:
SUBMITTER: Scholes C
PROVIDER: S-EPMC5469051 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Scholes Clarissa C DePace Angela H AH Sánchez Álvaro Á
Cell systems 20161229 1
Cells decide when, where, and to what level to express their genes by "computing" information from transcription factors (TFs) binding to regulatory DNA. How is the information contained in multiple TF-binding sites integrated to dictate the rate of transcription? The dominant conceptual and quantitative model is that TFs combinatorially recruit one another and RNA polymerase to the promoter by direct physical interactions. Here, we develop a quantitative framework to explore kinetic control, an ...[more]