Ontology highlight
ABSTRACT:
SUBMITTER: Kague E
PROVIDER: S-EPMC5469377 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Kague Erika E Roy Paula P Asselin Garrett G Hu Gui G Simonet Jacqueline J Stanley Alexandra A Albertson Craig C Fisher Shannon S
Developmental biology 20160316 2
During growth, individual skull bones overlap at sutures, where osteoblast differentiation and bone deposition occur. Mutations causing skull malformations have revealed some required genes, but many aspects of suture regulation remain poorly understood. We describe a zebrafish mutation in osterix/sp7, which causes a generalized delay in osteoblast maturation. While most of the skeleton is patterned normally, mutants have specific defects in the anterior skull and upper jaw, and the top of the s ...[more]