Neurocognitive outcomes among children who experienced seizures during treatment for acute lymphoblastic leukemia.

ABSTRACT:

Background

Limited information is available regarding neurocognitive outcomes of children who experience seizures during treatment for acute lymphoblastic leukemia (ALL). Accordingly, the main objectives of this study were to determine the incidence and risk factors for treatment-related seizures among children with ALL, and the neurocognitive outcomes associated with treatment-related seizures.

Procedure

Prospective neuropsychological assessment and magnetic resonance imaging (MRI) were planned for all 498 patients with newly diagnosed ALL enrolled on the St. Jude Total Therapy XV (TOTXV) protocol at three time points. The study database was reviewed retrospectively to identify those with treatment-related seizure. To assess neurocognitive changes associated with seizure, e

SUBMITTER: Nassar SL 

PROVIDER: S-EPMC5469699 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature