Ontology highlight
ABSTRACT:
SUBMITTER: Mahmoud MM
PROVIDER: S-EPMC5469771 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Mahmoud Marwa M MM Serbanovic-Canic Jovana J Feng Shuang S Souilhol Celine C Xing Rouyu R Hsiao Sarah S Mammoto Akiko A Chen Jing J Ariaans Markus M Francis Sheila E SE Van der Heiden Kim K Ridger Victoria V Evans Paul C PC
Scientific reports 20170613 1
Blood flow influences atherosclerosis by generating wall shear stress, which alters endothelial cell (EC) physiology. Low shear stress induces dedifferentiation of EC through a process termed endothelial-to-mesenchymal transition (EndMT). The mechanisms underlying shear stress-regulation of EndMT are uncertain. Here we investigated the role of the transcription factor Snail in low shear stress-induced EndMT. Studies of cultured EC exposed to flow revealed that low shear stress induced Snail expr ...[more]