Ontology highlight
ABSTRACT:
SUBMITTER: Kim TS
PROVIDER: S-EPMC5469788 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Kim Tae Sung TS Shin Yern-Hyerk YH Lee Hye-Mi HM Kim Jin Kyung JK Choe Jin Ho JH Jang Ji-Chan JC Um Soohyun S Jin Hyo Sun HS Komatsu Masaaki M Cha Guang-Ho GH Chae Han-Jung HJ Oh Dong-Chan DC Jo Eun-Kyeong EK
Scientific reports 20170613 1
The induction of host cell autophagy by various autophagy inducers contributes to the antimicrobial host defense against Mycobacterium tuberculosis (Mtb), a major pathogenic strain that causes human tuberculosis. In this study, we present a role for the newly identified cyclic peptides ohmyungsamycins (OMS) A and B in the antimicrobial responses against Mtb infections by activating autophagy in murine bone marrow-derived macrophages (BMDMs). OMS robustly activated autophagy, which was essentiall ...[more]