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Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery.

ABSTRACT: A new acidly sensitive PEGylated polyethylenimine linked by Schiff base (PEG-s-PEI) was designed to render pH-sensitive PEGylation nanoassemblies through multiple interactions with indomethacin and docetaxel (DTX). DTX nanoassemblies driven by PEG-s-PEI thus formulated exhibited an excellent pH-sensitivity PEGylation cleavage performance at extracellular pH of tumor microenvironment, compared to normal tissues, thereby long circulated in blood but were highly phagocytosed by tumor cells. Consequently, this smart pH-sensitive PEGylation cleavage provided an efficient strategy to target tumor microenvironment, in turn afforded superior therapeutic outcome in anti-tumor activity.

SUBMITTER: Zhao G

PROVIDER: S-EPMC5469818 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery.

Zhao Guanren G Long Ling L Zhang Lina L Peng Mingli M Cui Ting T Wen Xiaoxun X Zhou Xing X Sun Lijun L Che Ling L

Scientific reports 20170613 1

A new acidly sensitive PEGylated polyethylenimine linked by Schiff base (PEG-s-PEI) was designed to render pH-sensitive PEGylation nanoassemblies through multiple interactions with indomethacin and docetaxel (DTX). DTX nanoassemblies driven by PEG-s-PEI thus formulated exhibited an excellent pH-sensitivity PEGylation cleavage performance at extracellular pH of tumor microenvironment, compared to normal tissues, thereby long circulated in blood but were highly phagocytosed by tumor cells. Consequ ...[more]

PMID: 28611459

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