NEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes.
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ABSTRACT:
SUBMITTER: Brulet R
PROVIDER: S-EPMC5470076 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
NEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes.
Brulet Rebecca R Matsuda Taito T Zhang Ling L Miranda Carlos C Giacca Mauro M Kaspar Brian K BK Nakashima Kinichi K Hsieh Jenny J
Stem cell reports 20170511 6
Currently, all methods for converting non-neuronal cells into neurons involve injury to the brain; however, whether neuronal transdifferentiation can occur long after the period of insult remains largely unknown. Here, we use the transcription factor NEUROD1, previously shown to convert reactive glial cells to neurons in the cortex, to determine whether astrocyte-to-neuron transdifferentiation can occur under physiological conditions. We utilized adeno-associated virus 9 (AAV9), which crosses th ...[more]
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