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MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer.


ABSTRACT: Despite the importance of molecular subtype classification of glioblastoma (GBM), the extent of extracellular vesicle (EV)-driven molecular and phenotypic reprogramming remains poorly understood. To reveal complex subpopulation dynamics within the heterogeneous intratumoral ecosystem, we characterized microRNA expression and secretion in phenotypically diverse subpopulations of patient-derived GBM stem-like cells (GSCs). As EVs and microRNAs convey information that rearranges the molecular landscape in a cell type-specific manner, we argue that intratumoral exchange of microRNA augments the heterogeneity of GSC that is reflected in highly heterogeneous profile of microRNA expression in GBM subtypes.

SUBMITTER: Godlewski J 

PROVIDER: S-EPMC5470095 | biostudies-literature |

REPOSITORIES: biostudies-literature

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