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ARLTS1 polymorphism is associated with an increased risk of familial cancer: evidence from a meta-analysis.

ABSTRACT: Adenosine diphosphate (ADP)-ribosylation factor-like tumour suppressor gene 1(ARLTS1) might be associated with an increased risk of several types of familial cancers. However, previous studies have shown that cancer susceptibility is not completely consistent with ARLTS1 polymorphisms, and the precise mechanism remains unknown. Therefore, we conducted a meta-analysis of case-control studies by searching the PubMed, Embase, OVID, Science Direct and Chinese National Knowledge Infrastructure (CNKI) databases. In total, 12 studies met the inclusion criteria and were included in this meta-analysis. Statistical analyses were performed using STATA 11.0 software. Overall, the Cys148Arg T?>?C variant significantly increased cancer risk (CC vs. TT: OR?=?1.27, 95% CI?=?1.15-1.41, P?

SUBMITTER: Jiang Y

PROVIDER: S-EPMC5470195 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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ARLTS1 polymorphism is associated with an increased risk of familial cancer: evidence from a meta-analysis.

Jiang Yan Y Zhao Chen-Yang CY Cheng Li-Chun LC Xu Bing B Lv Hui-Yi HY

Hereditary cancer in clinical practice 20170613

Adenosine diphosphate (ADP)-ribosylation factor-like tumour suppressor gene 1(ARLTS1) might be associated with an increased risk of several types of familial cancers. However, previous studies have shown that cancer susceptibility is not completely consistent with ARLTS1 polymorphisms, and the precise mechanism remains unknown. Therefore, we conducted a meta-analysis of case-control studies by searching the PubMed, Embase, OVID, Science Direct and Chinese National Knowledge Infrast ...[more]

PMID: 28630657

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