Ontology highlight
ABSTRACT:
SUBMITTER: Zeiderman MR
PROVIDER: S-EPMC5470628 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Zeiderman Matthew R MR Morgan Desiree E DE Christein John D JD Grizzle William E WE McMasters Kelly M KM McNally Lacey R LR
ACS biomaterials science & engineering 20160606 7
We present a cancer nanomedicine based on acidic pH targeted gold nanorods designed for multispectral optoacoustic tomography (MSOT). We have designed gold nanorods coated with mesoporous silica and subsequently capped with chitosan (CMGs). We have conjugated pH-sensitive variant 7 pHLIP peptide to the CMGs (V7-CMG) to provide targeting specificity to the acidic tumor microenvironment. <i>In vitro</i>, treatment of S2VP10 and MiaPaca2 cells with V7-CMG containing gemcitabine resulted in signific ...[more]