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Triple-negative breast cancer in African-American women: disparities versus biology.


ABSTRACT: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionately affects BRCA1 mutation carriers and young women of African origin. There is evidence that African-American women with TNBC have worse clinical outcomes than women of European descent. However, it is unclear whether survival differences persist after adjusting for disparities in access to health-care treatment, co-morbid disease and income. It remains controversial whether TNBC in African-American women is a molecularly distinct disease or whether African-American women have a higher incidence of aggressive biology driven by disparities: there is evidence in support of both. Understanding the relative contributions of biology and disparities is essential for improving the poor survival rate of African-American women with TNBC.

SUBMITTER: Dietze EC 

PROVIDER: S-EPMC5470637 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Triple-negative breast cancer in African-American women: disparities versus biology.

Dietze Eric C EC   Sistrunk Christopher C   Miranda-Carboni Gustavo G   O'Regan Ruth R   Seewaldt Victoria L VL  

Nature reviews. Cancer 20150212 4


Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionately affects BRCA1 mutation carriers and young women of African origin. There is evidence that African-American women with TNBC have worse clinical outcomes than women of European descent. However, it is unclear whether survival differences persist after adjusting for disparities in access to health-care treatment, co-morbid disease and income. It remains controversial whether TNBC in African-American  ...[more]

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