Ontology highlight
ABSTRACT:
SUBMITTER: Manzoni G
PROVIDER: S-EPMC5470872 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Manzoni Giulia G Marinach Carine C Topçu Selma S Briquet Sylvie S Grand Morgane M Tolle Matthieu M Gransagne Marion M Lescar Julien J Andolina Chiara C Franetich Jean-François JF Zeisel Mirjam B MB Huby Thierry T Rubinstein Eric E Snounou Georges G Mazier Dominique D Nosten François F Baumert Thomas F TF Silvie Olivier O
eLife 20170516
<i>Plasmodium</i> sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, <i>Plasmodium falciparum</i> and <i>Plasmodium vivax</i>, rely on two distinct ...[more]