Ontology highlight
ABSTRACT:
SUBMITTER: Xiao Q
PROVIDER: S-EPMC5471002 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Xiao Qiang Q Yang Yu Y An Qing Q Qi Yong Y
Oncotarget 20170501 21
Osteosarcoma (OS) is a prevalent cancer worldwide. MicroRNAs (miRNAs) play critical roles in the growth, invasion and carcinogenesis of OS, whereas the underlying mechanisms remain ill-defined. Here, we addressed these questions. We detected significantly higher levels of ZNRF2, a ubiquitin ligase of the RING superfamily, and significantly lower levels of miR-100 in the OS specimens, compared to the paired normal bone tissues. The levels of ZNRF2 and miR-100 inversely correlated in the OS specim ...[more]