Ontology highlight
ABSTRACT:
SUBMITTER: Shi C
PROVIDER: S-EPMC5471030 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Shi Chen C Wang Yang Y Guo Yuna Y Chen Yijun Y Liu Nan N
Oncotarget 20170501 21
Dimethylaminoparthenolide (DMAPT), a water-soluble analogue of natural product parthenolide, possesses anti-inflammatory and anti-tumor activities. Despite that the anti-inflammatory mechanism of DMAPT has been well studied, specific target(s) for DMPAT and its anti-tumor mechanism remain poorly understood. In this study, to assess the anti-proliferative effects of DMAPT in pancreatic cancer cell lines and exploit its anti-tumor mechanism, serial affinity chromatograph was implemented to probe p ...[more]