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CaNAT1, a heterologous dominant selectable marker for transformation of Candida albicans and other pathogenic Candida species.


ABSTRACT: A dominant selectable marker for Candida albicans and other Candida species, which confers resistance to nourseothricin, was characterized. In a heterologous promoter system and a recyclable cassette, the marker efficiently permitted deletion and complementation of C. albicans genes. Neither growth nor filamentous development was affected in strains expressing this marker.

SUBMITTER: Shen J 

PROVIDER: S-EPMC547112 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature

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CaNAT1, a heterologous dominant selectable marker for transformation of Candida albicans and other pathogenic Candida species.

Shen Junqing J   Guo Weihui W   Köhler Julia R JR  

Infection and immunity 20050201 2


A dominant selectable marker for Candida albicans and other Candida species, which confers resistance to nourseothricin, was characterized. In a heterologous promoter system and a recyclable cassette, the marker efficiently permitted deletion and complementation of C. albicans genes. Neither growth nor filamentous development was affected in strains expressing this marker. ...[more]

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