IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity.
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ABSTRACT:
SUBMITTER: Pearson MJ
PROVIDER: S-EPMC5471184 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
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IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity.
Pearson Mark J MJ Herndler-Brandstetter Dietmar D Tariq Mohammad A MA Nicholson Thomas A TA Philp Ashleigh M AM Smith Hannah L HL Davis Edward T ET Jones Simon W SW Lord Janet M JM
Scientific reports 20170614 1
Increasing evidence suggests that inflammation plays a central role in driving joint pathology in certain patients with osteoarthritis (OA). Since many patients with OA are obese and increased adiposity is associated with chronic inflammation, we investigated whether obese patients with hip OA exhibited differential pro-inflammatory cytokine signalling and peripheral and local lymphocyte populations, compared to normal weight hip OA patients. No differences in either peripheral blood or local ly ...[more]
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