Ontology highlight
ABSTRACT:
SUBMITTER: Hashimoto K
PROVIDER: S-EPMC5471282 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Hashimoto Kenji K Ishima Tamaki T Sato Yasunori Y Bruno Davide D Nierenberg Jay J Marmar Charles R CR Zetterberg Henrik H Blennow Kaj K Pomara Nunzio N
Scientific reports 20170614 1
Major depressive disorder (MDD) in the elderly is a risk factor for dementia, but the precise biological basis remains unknown, hampering the search for novel biomarkers and treatments. In this study, we performed metabolomics analysis of cerebrospinal fluid (CSF) from cognitively intact elderly patients (N = 28) with MDD and age- and gender-matched healthy controls (N = 18). The CSF levels of 177 substances were measured, while 288 substances were below the detection limit. Only ascorbic acid w ...[more]