Ontology highlight
ABSTRACT:
SUBMITTER: Yasuhiko Y
PROVIDER: S-EPMC5471307 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Yasuhiko Yukuto Y Hirabayashi Yoko Y Ono Ryuichi R
Frontiers in chemistry 20170615
Retrotransposons are abundant in mammalian genomes and can modulate the gene expression of surrounding genes by disrupting endogenous binding sites for transcription factors (TFs) or providing novel TFs binding sites within retrotransposon sequences. Here, we show that a (C/T)CACACCT sequence motif in ORR1A, ORR1B, ORR1C, and ORR1D, Long Terminal Repeats (LTRs) of MaLR endogenous retrovirus (ERV), is the direct target of Tbx6, an evolutionary conserved family of T-box TFs. Moreover, by comparing ...[more]