Ontology highlight
ABSTRACT:
SUBMITTER: Kitamoto T
PROVIDER: S-EPMC5471328 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Kitamoto Takuya T Takai-Todaka Reiko R Kato Akiko A Kanamori Kumiko K Takagi Hirotaka H Yoshida Kazuhiro K Katayama Kazuhiko K Nakanishi Akira A
Frontiers in microbiology 20170615
Laboratory adaptation of viruses is an essential technique for basic virology research, including the generation of attenuated vaccine strains, although the principles of cell adaptation remain largely unknown. Deep sequencing of murine norovirus (MuNoV) S7 during serial passages in RAW264.7 cells showed that the frequencies of viral variants were altered more dynamically than previously reported. Serial passages of the virus following two different multiplicity of infections gave rise to distin ...[more]