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Hypochloraemia is strongly and independently associated with mortality in patients with chronic heart failure.


ABSTRACT: Hyponatraemia is strongly associated with adverse outcomes in heart failure. However, accumulating evidence suggests that chloride may play an important role in renal salt sensing and regulation of neurohormonal and sodium-conserving pathways. Our objective was to determine the prognostic importance of hypochloraemia in patients with heart failure.Patients in the BEST trial with baseline serum chloride values were evaluated (n?=?2699). Hypochloraemia was defined as a serum chloride ?96?mmol/L and hyponatraemia as serum sodium ?135?mmol/L. Hypochloraemia was present in 13.0% and hyponatraemia in 13.7% of the population. Chloride and sodium were only modestly correlated (r?=?0.53), resulting in only 48.7% of hypochloraemic patients having concurrent hyponatraemia. Both hyponatraemia and hypochloraemia identified a population with greater disease severity; however, renal function tended to be worse and loop diuretic doses higher with hypochloraemia. In univariate analysis, lower serum sodium or serum chloride as continuous parameters were each strongly associated with mortality (P?

SUBMITTER: Testani JM 

PROVIDER: S-EPMC5471359 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Hypochloraemia is strongly and independently associated with mortality in patients with chronic heart failure.

Testani Jeffrey M JM   Hanberg Jennifer S JS   Arroyo Juan Pablo JP   Brisco Meredith A MA   Ter Maaten Jozine M JM   Wilson F Perry FP   Bellumkonda Lavanya L   Jacoby Daniel D   Tang W H Wilson WH   Parikh Chirag R CR  

European journal of heart failure 20160113 6


<h4>Aims</h4>Hyponatraemia is strongly associated with adverse outcomes in heart failure. However, accumulating evidence suggests that chloride may play an important role in renal salt sensing and regulation of neurohormonal and sodium-conserving pathways. Our objective was to determine the prognostic importance of hypochloraemia in patients with heart failure.<h4>Methods and results</h4>Patients in the BEST trial with baseline serum chloride values were evaluated (n = 2699). Hypochloraemia was  ...[more]

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