Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC5471492 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Xu Jingfei J Zhao Lingyun L Xu Yuanyuan Y Zhao Weixing W Sung Patrick P Wang Hong-Wei HW
Nature structural & molecular biology 20161212 1
The central step in eukaryotic homologous recombination (HR) is ATP-dependent DNA-strand exchange mediated by the Rad51 recombinase. In this process, Rad51 assembles on single-stranded DNA (ssDNA) and generates a helical filament that is able to search for and invade homologous double-stranded DNA (dsDNA), thus leading to strand separation and formation of new base pairs between the initiating ssDNA and the complementary strand within the duplex. Here, we used cryo-EM to solve the structures of ...[more]