Ontology highlight
ABSTRACT:
SUBMITTER: Xiang J
PROVIDER: S-EPMC5472598 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Xiang Jinnan J Zhang Yiqun Y Bao Dandan D Cao Na N Zhang Xin X Li Ping P Qiu Shoutao S Guo Jigang J He Dan D Li Baojie B Yao Liqing L Liu Huijuan H
Scientific reports 20170615 1
The gastrointestinal tract is responsible for food digestion and absorption. The muscularis propria propels the foodstuff through the GI tract and defects in intestine motility may cause obstruction disorders. Our present genetic studies identified non-receptor tyrosine kinase c-Abl as an important regulator of the muscularis propria homeostasis and a risk factor for rectal prolapse. Mouse deficient for c-Abl showed defects in the muscularis propria of gastrointestinal tract and older c-Abl <sup ...[more]