Ontology highlight
ABSTRACT:
SUBMITTER: Munoz-Ballester C
PROVIDER: S-EPMC5472677 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Muñoz-Ballester Carmen C Berthier Arnaud A Viana Rosa R Sanz Pascual P
Biochimica et biophysica acta 20160311 6
Lafora disease (LD, OMIM 254780) is a fatal rare disorder characterized by epilepsy and neurodegeneration. Although in recent years a lot of information has been gained on the molecular basis of the neurodegeneration that accompanies LD, the molecular basis of epilepsy is poorly understood. Here, we present evidence indicating that the homeostasis of glutamate transporter GLT-1 (EAAT2) is compromised in mouse models of LD. Our results indicate that primary astrocytes from LD mice have reduced ca ...[more]