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Genome-wide association study identifies multiple risk loci for renal cell carcinoma.

ABSTRACT: Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10-10), 3p22.1 (rs67311347, P=2.5 × 10-8), 3q26.2 (rs10936602, P=8.8 × 10-9), 8p21.3 (rs2241261, P=5.8 × 10-9), 10q24.33-q25.1 (rs11813268, P=3.9 × 10-8), 11q22.3 (rs74911261, P=2.1 × 10-10) and 14q24.2 (rs4903064, P=2.2 × 10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.

SUBMITTER: Scelo G 

PROVIDER: S-EPMC5472706 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Genome-wide association study identifies multiple risk loci for renal cell carcinoma.

Scelo Ghislaine G   Purdue Mark P MP   Brown Kevin M KM   Johansson Mattias M   Wang Zhaoming Z   Eckel-Passow Jeanette E JE   Ye Yuanqing Y   Hofmann Jonathan N JN   Choi Jiyeon J   Foll Matthieu M   Gaborieau Valerie V   Machiela Mitchell J MJ   Colli Leandro M LM   Li Peng P   Sampson Joshua N JN   Abedi-Ardekani Behnoush B   Besse Celine C   Blanche Helene H   Boland Anne A   Burdette Laurie L   Chabrier Amelie A   Durand Geoffroy G   Le Calvez-Kelm Florence F   Prokhortchouk Egor E   Robinot Nivonirina N   Skryabin Konstantin G KG   Wozniak Magdalena B MB   Yeager Meredith M   Basta-Jovanovic Gordana G   Dzamic Zoran Z   Foretova Lenka L   Holcatova Ivana I   Janout Vladimir V   Mates Dana D   Mukeriya Anush A   Rascu Stefan S   Zaridze David D   Bencko Vladimir V   Cybulski Cezary C   Fabianova Eleonora E   Jinga Viorel V   Lissowska Jolanta J   Lubinski Jan J   Navratilova Marie M   Rudnai Peter P   Szeszenia-Dabrowska Neonila N   Benhamou Simone S   Cancel-Tassin Geraldine G   Cussenot Olivier O   Baglietto Laura L   Boeing Heiner H   Khaw Kay-Tee KT   Weiderpass Elisabete E   Ljungberg Borje B   Sitaram Raviprakash T RT   Bruinsma Fiona F   Jordan Susan J SJ   Severi Gianluca G   Winship Ingrid I   Hveem Kristian K   Vatten Lars J LJ   Fletcher Tony T   Koppova Kvetoslava K   Larsson Susanna C SC   Wolk Alicja A   Banks Rosamonde E RE   Selby Peter J PJ   Easton Douglas F DF   Pharoah Paul P   Andreotti Gabriella G   Freeman Laura E Beane LEB   Koutros Stella S   Albanes Demetrius D   Männistö Satu S   Weinstein Stephanie S   Clark Peter E PE   Edwards Todd L TL   Lipworth Loren L   Gapstur Susan M SM   Stevens Victoria L VL   Carol Hallie H   Freedman Matthew L ML   Pomerantz Mark M MM   Cho Eunyoung E   Kraft Peter P   Preston Mark A MA   Wilson Kathryn M KM   Michael Gaziano J J   Sesso Howard D HD   Black Amanda A   Freedman Neal D ND   Huang Wen-Yi WY   Anema John G JG   Kahnoski Richard J RJ   Lane Brian R BR   Noyes Sabrina L SL   Petillo David D   Teh Bin Tean BT   Peters Ulrike U   White Emily E   Anderson Garnet L GL   Johnson Lisa L   Luo Juhua J   Buring Julie J   Lee I-Min IM   Chow Wong-Ho WH   Moore Lee E LE   Wood Christopher C   Eisen Timothy T   Henrion Marc M   Larkin James J   Barman Poulami P   Leibovich Bradley C BC   Choueiri Toni K TK   Mark Lathrop G G   Rothman Nathaniel N   Deleuze Jean-Francois JF   McKay James D JD   Parker Alexander S AS   Wu Xifeng X   Houlston Richard S RS   Brennan Paul P   Chanock Stephen J SJ  

Nature communications 20170609

Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10<sup>-10</sup>), 3p22.1 (rs673113  ...[more]

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