Ontology highlight
ABSTRACT:
SUBMITTER: Liang J
PROVIDER: S-EPMC5472764 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Liang Jingjing J Lyu Jun J Zhao Meng M Li Dan D Zheng Mingzhu M Fang Yan Y Zhao Fangzhu F Lou Jun J Guo Chuansheng C Wang Lie L Wang Di D Liu Wanli W Lu Linrong L
Nature communications 20170609
Thymocyte-expressed, positive selection-associated 1 (Tespa1) is important in T cell receptor (TCR)-driven thymocyte development. Downstream of the TCR, Tespa1 is a crucial component of the linker for activation of T cells (LAT) signalosome, facilitating calcium signalling and subsequent MAPK activation. However, it is unknown how Tespa1 elicits calcium signalling. Here, we show that inositol 1,4,5-trisphosphate receptor type 1 (IP3R1) is crucial for Tespa1-optimized, TCR-induced Ca<sup>2+</sup> ...[more]