Ontology highlight
ABSTRACT:
SUBMITTER: Ni Q
PROVIDER: S-EPMC5472774 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Ni Qicheng Q Gu Yanyun Y Xie Yun Y Yin Qinglei Q Zhang Hongli H Nie Aifang A Li Wenyi W Wang Yanqiu Y Ning Guang G Wang Weiqing W Wang Qidi Q
Nature communications 20170609
Diabetes is associated with beta cell mass loss and islet dysfunctions. mTORC1 regulates beta cell survival, proliferation and function in physiological and pathological conditions, such as pregnancy and pancreatectomy. Here we show that deletion of Raptor, which is an essential component of mTORC1, in insulin-expressing cells promotes hypoinsulinemia and glucose intolerance. Raptor-deficient beta cells display reduced glucose responsiveness and exhibit a glucose metabolic profile resembling fet ...[more]