Ontology highlight
ABSTRACT:
SUBMITTER: Sun X
PROVIDER: S-EPMC5472784 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Sun Xiangzhong X Li Yaxin Y He Wenrong W Ji Chenggong C Xia Peixue P Wang Yichuan Y Du Shuo S Li Hongjiang H Raikhel Natasha N Xiao Junyu J Guo Hongwei H
Nature communications 20170612
Ethylene is an important phytohormone that promotes the ripening of fruits and senescence of flowers thereby reducing their shelf lives. Specific ethylene biosynthesis inhibitors would help to decrease postharvest loss. Here, we identify pyrazinamide (PZA), a clinical drug used to treat tuberculosis, as an inhibitor of ethylene biosynthesis in Arabidopsis thaliana, using a chemical genetics approach. PZA is converted to pyrazinecarboxylic acid (POA) in plant cells, suppressing the activity of 1- ...[more]