Vibrio cholerae ensures function of host proteins required for virulence through consumption of luminal methionine sulfoxide.
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ABSTRACT:
SUBMITTER: Vanhove AS
PROVIDER: S-EPMC5473594 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Vibrio cholerae ensures function of host proteins required for virulence through consumption of luminal methionine sulfoxide.
Vanhove Audrey S AS Hang Saiyu S Vijayakumar Vidhya V Wong Adam Cn AC Asara John M JM Watnick Paula I PI
PLoS pathogens 20170606 6
Vibrio cholerae is a diarrheal pathogen that induces accumulation of lipid droplets in enterocytes, leading to lethal infection of the model host Drosophila melanogaster. Through untargeted lipidomics, we provide evidence that this process is the product of a host phospholipid degradation cascade that induces lipid droplet coalescence in enterocytes. This infection-induced cascade is inhibited by mutation of the V. cholerae glycine cleavage system due to intestinal accumulation of methionine sul ...[more]
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2022-12-01 | GSE213598 | GEO