Evolutionary origin of type IV classical cadherins in arthropods.

ABSTRACT:

Background

Classical cadherins are a metazoan-specific family of homophilic cell-cell adhesion molecules that regulate morphogenesis. Type I and type IV cadherins in this family function at adherens junctions in the major epithelial tissues of vertebrates and insects, respectively, but they have distinct, relatively simple domain organizations that are thought to have evolved by independent reductive changes from an ancestral type III cadherin, which is larger than derived paralogs and has a complicated domain organization. Although both type III and type IV cadherins have been identified in hexapods and branchiopods, the process by which the type IV cadherin evolved is still largely unclear.

Results

Through an analysis of arthropod genome sequences, we found that the only c

SUBMITTER: Sasaki M 

PROVIDER: S-EPMC5473995 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature